Schedule of Events
(Preliminary Information—Please consult on-site notices for last-minute updates.)
“Applied Reproductive Biology: Making It Relevant”
SSR 45th Annual Meeting and 18th Ovarian Workshop
Hosted by the Center for Reproductive Biology and Health
The Pennsylvania State University
State College, Pennsylvania
Friday, 10 August 2012
3:00–5:00 pm
Finance Committee Meeting.
7:00–10:00 pm
Board of Directors Meeting.
Saturday, 11 August 2012
8:00 am–5:00 pm
Board of Directors Meeting.
1:00 pm–7:00 pm
Registration. HUB-Robeson Center.
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Sunday, 12 August 2012
7:30–8:00 am
Trainee Forum Breakfast. Thomas Building, Room 100.
- Dori C. Woods, Ph.D. (Vincent Center for Reproductive Biology, Boston, Massachusetts, USA).
8:00 am–1:00 pm
Editorial Retreat. Specific times to be determined.
8:00–11:00 am
Trainee Forum—Writing Winning Grants. Thomas Building, Room 100.
- Stuart B. Moss, Ph.D., and Susan Taymans, Ph.D. (Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Rockville, Maryland, USA).
10:00 am–7:00 pm
Slide Preview Room. Life Sciences Building, Room 006.
Registration. HUB-Robeson Center.
11:15–11:45 am
Volunteers Meeting.
11:45 Am–12:15 pm
Session Chairs Meeting.
1:45–2:15 pm
Opening Ceremony. Eisenhower Auditorium.
- Welcome to the SSR's 45th Annual Meeting and the 18th Ovarian Workshop! Barbara C. Vanderhyden, Ph.D. (Ottawa Hospital Research Institute, Ottawa, Ontario, Canada), President, SSR.
- Remarks: Joy L. Pate, Ph.D. (The Pennsylvania State University, State College, Pennsylvania, USA), Chair, SSR Local Arrangements Committee; Mary B. Zelinski, Ph.D. (Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon), Chair, SSR Program Committee.
2:15–3:45 pm
President’s Symposium. (Supported by an unrestricted grant from Ferring Pharmaceuticals). Eisenhower Auditorium. Chair: Barbara C. Vanderhyden, Ph.D. (Ottawa Hospital Research Institute, Ottawa, Ontario, Canada), President, SSR.
- Patrick Lonergan, Ph.D. (University of Dublin, Dublin, Ireland). Current Challenges and Translational Research Associated with Dairy Cattle Infertility (Abstract 2).
- W. Hamish Wallace, M.D. (Royal Hospital for Sick Children, Edinburgh, Scotland, Great Britain). Fertility Preservation for Young People with Cancer: What Are the Remaining Challenges? (Abstract 3).
4:15–5:00 pm
Anita Payne New Perspectives in Reproductive Biology Lecture. (Supported by the Anita Payne Endowment Fund.) Eisenhower Auditorium.
- Lori T. Raetzman, Ph.D. (University of Illinois, Urbana, Illinois). Development of the Pituitary, Gatekeeper of Gonadotropins (Abstract 4).
5:00–6:00 pm
Awards Ceremony. Eisenhower Auditorium.
- Welcome and Introduction: Robert Viger, Ph.D. (Laval University, Quebec City, Quebec, Canada), Chair, SSR Awards Committee.
- SSR New Investigator Award (supported by the Virendra B. Mahesh New Investigator Fund): Jon M. Oatley, Ph.D. (Washington State University, Pullman, Washington, USA).
- Trainee-Mentoring Award (supported by the SSR Trainee-Mentoring Fund): R. Michael Roberts, Ph.D. (University of Missouri, Columbia, Missouri, USA).
- SSR Research Award: Sylvie Breton, Ph.D. (Harvard Medical School, Boston, Massachusetts, USA).
- Distinguished Service Award (supported by EMD Serono Research Institute): Barbara M. Sanborn, Ph.D. (Colorado State University, Fort Collins, Colorado, USA).
- Carl G. Hartman Award (supported by Cook Medical): Douglas M. Stocco, Ph.D. (Texas Tech University Health Sciences Center, Lubbock, Texas, USA).
6:00–7:30 pm
Opening Reception. Millennium Science Complex.
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Monday, 13 August 2012
6:00–7:30 am
SSR 2012 RUN/WALK for Reproductive Fitness. (Registration required; more information here.)
7:30 am–5:00 pm
Slide Preview Room. Life Sciences Building, Room 006.
Registration. HUB-Robeson Center.
7:45–9:30 am
Exhibits Open. HUB-Robeson Center, Lounge.
Poster Session A. HUB-Robeson Center, Alumni Hall.
9:45 – 10:30 am
SSR New Investigator Lecture Eisenhower Auditorium.
- Jon M. Oatley, Ph.D. (Washington State University, Pullman, Washington, USA). Molecular Regulation of Fate Determination in Male Germline Stem Cells (Abstract 5).
10:30–12:00 noon
Trainee Research Platform Competition (supported by EMD Serono Research Institute). Eisenhower Auditorium. Chair: Robert Viger, Ph.D. (Laval University, Quebec City, Quebec, Canada)
12:00–1:00 pm
Lunch. Box lunches available for purchase on the registration form.
1:00–4:45 pm
Modules I A–IV A (Four concurrent sessions). Forum Building, Rooms 102, 105, 108, 111.
Module I A: Ovarian Workshop. Room 102.
- The Oocyte. Chair: Christos Coutifaris, M.D., Ph.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA).
- Trudee Fair, Ph.D. (University College Dublin, Dublin, Ireland). Oocyte Development in Cattle: Factors Affecting Competence (Abstract 12).
- Daniel A. Dumesic, M.D. (University of California, Los Angeles, California, USA). The PCOS Oocyte and Its Microenvironment (Abstract 13).
- Andrew Pask, Ph.D. (University of Connecticut, Storrs, Connecticut, USA). A Role for Estrogen in Somatic Cell Fate of the Mammalian Gonad (Abstract 14).
- Debate: Can We and Should We Be Freezing Oocytes from Humans? Chair: Clarisa R. Gracia, M.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA).
- Nicole Noyes, M.D. (NYU Fertility Center, New York, New York, USA). Oocyte Cryopreservation: Can We and Should We Be Freezing Oocytes from Humans? (Abstract 15).
- David F. Albertini, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA). What We Know and Don't Know about Human Oocyte Cryopreservation (Abstract 16).
- Platform Session: Follicles. Chair: Jock Findlay, Ph.D. (Prince Henry's Institute, Victoria, Australia).
- Platform Speaker: Suzanne M. Quartuccio. (University of Illinois at Chicago, Chicago, Illinois, USA). Targeted Smad2-dominant Negative Expression Induces Oviductal-like Ovarian Cysts and Tumors Irrespective of p53 Deletion in the Ovarian Surface or Oviductal Epithelium (Abstract 17).
- Platform Speaker: Lesya M. Holets, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA). Spaceflight Inhibits Ovarian Follicle Development, Induces Down-regulation of Estrogen Receptor Alpha, and Alters Metabolic Pathways and Gene Expression in Mouse Uterus (Abstract 18).
- Platform Speaker: Pengpeng Ma, Ph.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA). Histone Deacetylase 2 (HDAC2) Regulates Chromosome Condensation via H4K16 Deacetylation During Oocyte Maturation in Mouse (Abstract 19).
Module II A: Dynamics of Testicular Function. Room 105.
- Homeostasis I. Chair: Douglas M. Stocco, Ph.D. (Texas Tech University School of Medicine, Lubbock, Texas, USA).
- Gerard Karsenty, M.D., Ph.D. (Columbia University Medical Center, New York, New York, USA). Endocrine Regulation of Male Fertility by the Skeleton (Abstract 20).
- Platform Speaker: Pengli Bu, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA). Origin of a Species-specific Rheostat Controlling Testicular Growth and Steroidogenesis (Abstract 21.)
- Platform Speaker: Rasmani Hazra (University of Sydney, Sydney, Australia). Effect of Temporal Sertoli Cell Androgen Receptor Expression on Leydig Cell Development and Function in Mice (Abstract 22.)
- Homeostasis II. Chair: Ralph G. Meyer, Ph.D. (University of Pennsyvlania, Philadelphia, Pennsylvania, USA).
- Marvin L. Meistrich, Ph.D. (University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA). Recovery of Spermatogenesis after Irradiation or Chemotherapy (Abstract 23).
- Jeffrey J.Lysiak, Ph.D. (University of Virginia School of Medicine, Charlottesville, Virginia, USA). Impaired Clearance of Apoptotic Germ Cells Leads to Disruption of the Blood Testis Barrier and Spermatogenesis (Abstract 24).
- Testis Immune Function. Chair: Kwan Hee Kim, Ph.D. (Washington State University, Pullman, Washington, USA).
- Mark P. Hedger, Ph.D. (Monash Institute of Medical Research, Clayton, Australia). Inflammatory and Immunoregulatory Signaling Pathways in Male Reproductive Function (Abstract 25).
- Jannette M. Dufour, Ph.D. (Texas Tech University Health Sciences Center, Lubbock, Texas, USA). Immune-privileged Sertoli Cells: Induction of Regulatory T Cells and Therapeutic Potential (Abstract 26).
Module III A: Reproductive Tract Biology and Pregnancy Outcomes. Room 108.
- Recent Concepts of Periimplantation Biology. Chair: Sudhansu K. Dey, Ph.D. (Cincinnati Children's Hospital, Cincinatti, Ohio, USA).
- Hyunjung Jade Lim, Ph.D. (Konkuk University, Seoul, Korea). Regulation of Autophagic Response in the Mouse Blastocyst (Abstract 27).
- D. Randall Armant, Ph.D. (Wayne State University, Detroit, Michigan, USA). Serotonin Signaling in Pre- and Peri-implanation Development Revealed in a Knockout Model (Abstract 28).
- Platform Speaker: Mallory E. Lindberg (Southern Illinois University, Carbondale, Illinois, USA). Altered Gene Expression Following Ablation of Cdh1 and Trp53 in the Uterus (Abstract 29).
- Platform Speaker: Huiting Ho (Prince Henry's Institute, Clayton, Victories, Australia). Modification of a Peptide Inhibitor of Proprotein Convertase for Use as a Vaginally-deliverable Contraceptive with Added Benefits (Abstract 30.)
- State-of-the-Art Talk. Chair: Sudhansu K. Dey, Ph.D. (Cincinnati Children's Hospital, Cincinatti, Ohio, USA).
- Jan J. Brosens, Ph.D. (Imperial College, London, England, United Kingdom). Decidualization as Biosensor of Embryo Viability (Abstract 31).
- Decidualization. Chair: Asgerally T. Fazleabas, Ph.D. (Michigan State University, Grand Rapids, Michigan, USA).
- Hugh S. Taylor, M.D. (Yale School of Medicine, New Haven, Connecticut, USA). Endometrial Stem Cells (Abstract 32).
- Gunter P. Wagner, Ph.D. (Yale University, New Haven Connecticut, USA). Origin of the Endometrial Gene Regulatory Network of Placental Mammals (Abstract 33).
Module IV A: Consequences of Maternal Diet on Offspring. Room 111.
- Obesity and Reproductive Dysfunction 1. Chair: Stephen P. Ford, Ph.D. (University of Wyoming, Laramie, Wyoming).
- Deborah J. Clegg, Ph.D. (University of Texas Southwestern Medical Center, Dallas, Texas, USA). It’s ALL in the Hypothalamus! Sex, Reproduction, and Obesity (Abstract 34).
- Antonio E. Frias, M.D. (Oregon Health & Science University, Portland, Oregon, USA). Maternal High Fat Diet Decreases Placental Blood Flow and Increases the Frequency of Stillbirth in a Non-human Primate Model of Excess Nutrition (Abstract 35).
- Platform Speaker: Tursunjan Nurmamat (University of Wyoming, Laramie, Wyoming, USA). Maternal Overnutrition/Obesity Programs Altered Pituitary Function Resulting in Increased Adiposity of Male Offspring (Abstract 36).
- Platform Speaker: Kristin A. Norwood (University of Nebraska–Lincoln, Lincoln, Nebraska, USA). Maternal Obesity Induces Placenta Oxidative Stress and Alters the Differentiation of Mesodermal Cells to the Myogenic Versus Adipogenic Lineage (Abstract 37).
- Young Investigator Seminar: Impact of Maternal Diet on Offspring. Chair: Sean W. Limesand, Ph.D. (University of Arizona, Tucson, Arizona, USA).
- Carey M. Satterfield, Ph.D. (Texas A&M University, College Station, Texas, USA). Differential Fetal Responses to Maternal Nutrient Restriction: A Population Variance Approach (Abstract 38).
- Platform Speaker: Angela L. Schenewerk (University of Missouri, Columbia, Missouri, USA). The Effect of Maternal High-Fat Diet and ART on Cardiovascular Outcome in Offspring (Abstract 39).
- Platform Speaker: Jack W. Pike (University of Delaware, Newark, Delaware, USA). Fetal Growth Restriction leads to Inhibition of Steroidogenesis (Abstract 40).
- Obesity and Reproductive Dysfunction 2. Chair: Sana M. Salih, M.D. (University of Wisconsin, Madison, Wisconsin, USA).
- Emily S. Jungheim, M.D. (Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA). Impact of Obesity on Oocyte and Embryo Outcome (Abstract 41).
- Platform Speaker: Stephen P. Ford, Ph.D. (Univeristy of Wyoming, Laramie, Wyoming, USA). Reduction of an Obesogenic Diet to Requirements in Early Gestation Alleviates Diet-induced Dysregulation in Glucose-insulin Dynamics and Fetal Adiposity in the Sheep (Abstract 42).
5:00–7:00 pm
NICHD Forum. (Abstract 43). Co-chairs: Louis V. DePaolo, Ph.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA) and Koji Yoshinaga, Ph.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA). Eisenhower Auditorium
- Alan E. Guttmacher, M.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA), The Future of Research: The View from NICHD.
- Louis V. DePaolo, Ph.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA), What the NICHD Reorganization Means for Support of Reproduction Research.
- Neelakanta Ravindranath, Ph.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA), USDA-NIH Partnerships.
- Charisee Lamar, Ph.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA), Cooperative Research Partnerships to Promote Workforce Diversity in the Reproductive Sciences.
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Tuesday, 14 August 2012
7:30 am–5:00 pm
Slide Preview Room. Life Sciences Building, Room 006.
Registration. HUB-Robeson Center.
8:00–9:30 am
Platform Sessions. (Six concurrent sessions.) Forum and Chambers Buildings.
- Platform Session 2. Corpus Luteum. (Abstracts 44–49). Forum Building, Room 108. Chair: Diane M. Duffy, Ph.D.
- Platform Session 3. Stem Cells. (Abstracts 50–55). Chambers Building, Room 101. Chair: Marie-Claude Hofmann, Ph.D.
- Platform Session 4. Reproductive Technologies (Abstracts 56–61). Forum Building, Room 111. Chair: Carol L. Keefer, Ph.D.
- Platform Session 5. Embryonic Development. (Abstracts 62–67). Forum Building, Room 105. Chair: Rebecca L. Krisher, Ph.D.
- Platform Session 6. Hormone Signaling. (Abstracts 68–73). Chambers Building, Room 112. Chair: Marta Tesone, Ph.D.
- Platform Session 7. Reproductive Toxicology. (Abstracts 74–79). Forum Building, Room 102. Chair: Joe A. Arosh, Ph.D., D.V.M.
9:00 am–12:00 pm
SSR Science Education Outreach Program. Ag Progress Days. Organized by Francisco Diaz, Ph.D. (Pennsylvania State University, State College, Pennsylvania, USA). Sponsored by SSR. This activity is supported by a generous grant from the Burroughs Wellcome Fund.
9:45–11:30 am
Exhibits Open. HUB-Robeson Center, Lounge.
Poster Session B. HUB-Robeson Center, Alumni Hall.
11:30 am–1:00 pm
Trainee-Mentor Luncheon. HUB-Robeson Center, Heritage Hall.
Break for Lunch. Attendees responsible for their own lunches.
Committee Meetings. Room assignments posted at SSR Registration Desk.
Exhibits Open by Appointment. HUB-Robeson Center.
1:00–5:30 pm
Modules I B–IV B (Four concurrent sessions). Forum Building.
Module I B: Ovarian Workshop. Forum Building, Room 102.
- Ovarian Cancer. Chair: Dale Buck Hales, Ph.D. (Southern Illinois University, Carbondale, Illinois, USA).
- Denise C. Connolly, Ph.D. (Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA). Development of Mouse Models to Study Ovarian Cancer Biology and Response Therapy (Abstract 80).
- Anne-Marie Mes-Masson, Ph.D. (University of Montreal, Montreal, Quebec, Canada). Biomarkers in Epithelial Ovarian Cancer—or Should We Go with the Flow? (Abstract 81).
- David Huntsman, M.D. (University of British Columbia, Vancouver, British Columbia, Canada). From Subtype-specific Biologic Insights to Subtype-specific Ovarian Cancer Control (Abstract 82).
- Debate: Cellular Origins of Ovarian Cancer. Chair: Barbara C. Vanderhyden, Ph.D. (Ottawa Hospital Research Institute, Ottawa, Canada).
- Louis Dubeau, M.D., Ph.D. (Keck Hospital of USC, Los Angeles, California, USA). An Origin from the Fallopian Tube Cannot Account for all Tumors Historically Regarded as of Primary Ovarian Origin (Abstract 83).
- Patricia A. Shaw, M.D. (Toronto General Hospital, Toronto, Ontario, Canada). The Fallopian Tube as a Primary Origin of Serous Ovarian Cancers. (Abstract 84).
- Ovulation and PCOS. Chair: Kate Hardy, Ph.D. (Imperial College, London, Great Britain).
- Thomas E. Curry, Jr., Ph.D. (University of Kentucky Medical Center, Lexington, Kentucky, USA). The Matrix Metalloproteinase System and Ovulation: Expression, Regulation, and Function in the Human and the Rat (Abstract 85).
- Darryl Russell, Ph.D. (University of Adelaide, Adelaide, Australia). Staying Flexible: Tissue Remodelling Required for Folliculogenesis and Ovulation (Abstract 86).
- Elisabet Stener-Victorin, Ph.D. (University of Gothenburg, Gothenburg, Sweden). Androgens and Development of PCOS—Effects of Non-pharmacological Treatment (Abstract 87).
- Ovarian Workshop Keynote Lecture. Chair: John J. Eppig, Ph.D. (The Jackson Laboratory, Bar Harbor, Maine, USA).
- Marco Conti, M.D. (University of California, San Francisco, California, USA). Oocyte Maternal mRNA Translation and Developmental Competence: A Genome-wide Analysis (Abstract 88).
Module II B: Dynamics of Testicular Function. Room 105.
- The Spermatogonial Stem Cell Niche. Chair: Marie-Claude Hofmann, Ph.D. (University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA).
- Luiz R. de Franca, Ph.D. (Federal University of Minas Gerais, Minas Gerais, Brazil). Spermatogonial Stem Cell Niche in the Collared Peccary and other Non-model Vertebrates (Abstract 89).
- Margaret T. Fuller, Ph.D. (Stanford University, Stanford, California). Regulation of Self-renewal and Differentiation of Spermtogonial Stem Cells by the Local Testis Microenvironment (Abstract 90).
- Platform Speaker: Pawan Puri, Ph.D. (University of Pittsburgh, Pittbsurgh, Pennsylvania, USA). The shp2 Tyrosine Phosphatase is Essential for Spermatogenesis and male Fertility (Abstract 91).
- Platform Speaker: Kevin M. Sargent (University of Nebraska, Lincoln, Nebraska, USA). Neuropilin-1 (nrp-1) Loss in Sertoli Cells Increases Testis Weight and Alters Expression of Genes Necessary for Undifferentiated Spermatogonia Self-renewal, Differentiation and Cell Survival (Abstract 92).
- The Spermatogonial Stem Cell Niche: State-of-the-Art Talk. Chair: John R. McCarrey, Ph.D. (University of Texas, San Antonio, Texas, USA).
- Antoine H.F.M. Peters, Ph.D. (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland). Molecular Determinants of Histone Retention in Mouse and Human Spermatozoa (Abstract 93).
- Epigenetic Regulation, Sperm Quality, Trans-generational Effects. Chair: John R. McCarrey, Ph.D. (University of Texas, San Antonio, Texas, USA).
- Richard M. Sharpe, Ph.D. (University of Edinburgh, Edinburgh, Scotland, United Kingdom). Susceptibility of the Fetal Testis to Disruption by Environmental Factors: Mechanisms and Species Differences (Abstract 94.)
- Michelle T. Lane, Ph.D. (University of Adelaide, Adelaide, Australia). You Are What Your Father Ate—Paternal Programming of Reproductive and Metabolic Health in Offspring (Abstract 95).
- Platform Speaker: Romain Lambrot, Ph.D. (McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada). Folate Deficiency Alters the Sperm Epigenome and Reproductive Outcomes (Abstract 96).
- Platform Speaker: Ralph G. Meyer, Ph.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA). Epigenetic Effect of Sperm Chromatin Composition on Early Embryonic Genome Activation (Abstract 97).
Module III B: Reproductive Tract Biology and Pregnancy Outcomes. Room 108.
- Regulation of Immune Responses in Reproductive Tissues. Chair: Karen E. Racicot, Ph.D. (Yale University, New Haven, Connecticut, USA).
- Jan Ernerudh, M.D., Ph.D. (Linköping University, Linköping, Sweden). Tolerance Mechanisms at the Fetal Maternal Interface: The Role of Decidual Macrophages (Abstract 98).
- Joy L. Pate, Ph.D. (Pennsylvania State University, State College, Pennsylvania). Immune Cells in the Ruminant Corpus Luteum: Friends or Foes? (Abstract 99).
- Platform Speaker: Uma Thiruchelvam (University of Edinburgh, Edinburgh, Scotland, Great Britain). Angiogenic Crosstalk Within the Endometrium Reveals a Pivotal role for the Endometrial Macrophage (Abstract 100).
- Platform Speaker: Kaiyu Kubota, Ph.D. (University of Kansas, Kansas City, Kansas, USA) Fosl1 Regulation of Trophoblast Cell Differentiation: Partners and Gene Targets (Abstract 101).
- Regulation of Immune Responses in Reproductive Tissues: State-of-the-Art Talk. Chair: Karen E. Racicot, Ph.D. (Yale University, New Haven, Connecticut, USA).
- Sarah A. Robertson, Ph.D. (University of Adelaide, Adelaide, Australia). Novel Models for Establishing the Role of Immune Cells in Reproductive Processes (Abstract 102).
- Immune Responses to Gestation Signals. Chair: Troy Lee Ott, Ph.D. (Pennsylvania State University, State College, Pennsylvania, USA).
- Gil G. Mor, M.D., Ph.D. (Yale School of Medicine, New Haven, Connecticut, USA). Toll-like Receptors and Inflammation During Pregnancy (Abstract 103).
- Thomas R. Hansen, Ph.D. (Colorado State University, Fort Collins, USA). Maternal/Fetal Infection with Virus Activates Interferon and Attenuates Chemokine Responses (Abstract 104).
- Platform Speaker: Bryce D. Warren (University of Kansas, Kansas City, Kansas, USA). Autoimmune Regulator (aire) Deficiency Is Associated with Embryonic Loss and Generation of Autoantibodies Against the Uterus, Placenta, and Embryo (Abstract 105).
- Platform Speaker: Daesuk Chung, Ph.D. (Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA). Uterine Deletion of Cmet Leads to Pregnancy Failure with Multiple Defects in Decidualization, Angiogenesis, and Placentation (Abstract 106).
Module IV B: Assisted Reproductive Technologies: Current Frontiers and Emerging Technologies. Room 111.
- SRF New Investigator Exchange Lecture. Chair: Rebecca L. Krisher, Ph.D. (National Foundation for Fertility Research, Lone Tree, Colorado, USA).
- Petros Marangos, Ph.D. (University of Ioannina, Ioannina, Greece). The DNA Damage Response in Mammalian Oocytes (Abtract 107).
- Impact of Maternal Factors on Embryonic Development. Chair: Rebeca L Krisher, Ph.D. (National Foundation for Fertility Research, Lone Tree, Colorado, USA).
- Aleksander Rajkovic, M.D., Ph.D. (Magee-Womens Research Institute and Foundation, Pittsburgh, Pennsylvania, USA). Molecular Mechanisms and Consequences of Premature Ovarian Aging (Abstract 108).
- Justin St. John, Ph.D. (Monash University, Clayton, Australia). The Control of Mitochondrial DNA Replication in Gametes, Embryos, and Early Development (Abstract 109).
- Assessment of Oocyte and Embryo Quality. Chair: Pierre Comizzoli, Ph.D., V.M.D. (Smithsonian Conservation Biology Institute, Washington, D.C., USA).
- Dagan Wells, Ph.D. (University of Oxford, Oxford, England, United Kingdom). Oocyte and Embryo Selection in Assisted Reproductive Treatments: Methods Improving Outcome and Illuminating Aspects of Meiosis and Embryogenesis. (Abstract 110).
- Claude Robert, Ph.D. (Universite Laval, Quebec, Quebec, Canada). Transcriptome Analyses of In Vitro-produced Embryos Suggest Developmental Competence and Embryo Quality Are Two Distinct Concepts (Abstract 111).
- Debate: ART—Is It Worth the Risk? Chair: Emre Seli, M.D. (Yale University School of Medicine, New Haven, Connecticut, USA).
- Carmen Sapienza, Ph.D. (Temple University School of Medicine, Philadelphia, Pennsylvania, USA). DNA Methylation and Gene Expression Differences Associated with Assisted Reproduction (Abstract 112).
- Richard T. Scott, M.D. (Robert Wood Johnson Medical School, Morristown, New Jersey, USA). Comprehensive Chromosome Screening of Human Embryos for ART Outcomes (Abstract 113).
- Assisted Reproductive Technology Platform Session.
- Platform Speaker: Paolo Rinaudo, M.D., Ph.D. (University of California–San Francisco, San Francisco, California, USA). Metabolic Differences in Serum and Liver Can Explain the Impaired Glucose Tolerance Found in Adult Mice Conceived by IVF (Abstract 114).
- Platform Speaker: Mirit Gendelman (The Hebrew University of Jerusalem, Rehovot, Israel). Incorporation of Coenzyme q10 into Bovine Oocytes Improves Mitochondrial Features and Alleviates Effects of Summer Thermal Stress on Developmental Competence (Abstract 115).
6:00–7:00 pm
Foundation for Biomedical Research Special Lecture. Forum Building, Room 105.
- Paul McKellips (Foundation for Biomedical Research, Washington, D.C., USA). Raising the Bar: The Biomedical Research Movement (Abstract 116).
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Wednesday, 15 August 2012
6:30–8:00 am
Past Presidents’ Breakfast.
7:30 am–5:00 pm
Slide Preview Room. Life Sciences Building, Room 006.
Registration. HUB-Robeson Center.
8:00–9:00 am
Keynote Lecture Eisenhower Auditorium.
- Anthony Atala, M.D. (Wake Forest University, Winston-Salem, North Carolina, USA). Regenerative Medicine: New Approaches to Healthcare (Abstract 117).
9:00 am–12:00 pm
SSR Science Education Outreach Program. Ag Progress Days. Organized by Francisco Diaz, Ph.D. (Pennsylvania State University, State College, Pennsylvania, USA). Sponsored by SSR. This activity is supported by a generous grant from the Burroughs Wellcome Fund.
9:15–11:00 am
Exhibits Open. HUB-Robeson Center, Lounge.
Poster Session C. HUB-Robeson Center, Alumni Hall.
11:15 am–12:45 pm
Heritage Luncheon. HUB-Robeson Center, Heritage Hall. (Tickets required, may be purchased on the registration form.)
- Pedro Verdugo, M.D. (University of Washington, Friday Harbor, Washington, USA). Of Trumpets, Gabriel, Richard And Albert: Gamete Tranport and Einstein’s Theorem of the Drunken Sailor (Abstract 118).
Minority Affairs Lunch Symposium. From Reproductive Biology to Reproductive Medicine. Osmond Building, Room 117.
- Sarah K. England, Ph.D. (Washington University in St. Louis, St. Louis, Missouri, USA). The Timing of Labor: A Scientist's Perspective (Abstract 119).
- Devon Payne-Sturges, Dr.P.H. (Environmental Protection Agency, Washington, D.C., USA). Humanizing Science: Making Research Relevant for Achieving Heath Equity (Abstract 120).
Break for Lunch. Attendees responsible for their own lunches.
Committee Meetings. Room assignments posted at SSR Registration Desk.
1:00–5:30 pm
Modules I C–IV C. Forum Building.
Module I C: Ovarian Workshop. Room 102.
- Ovarian Toxicology. Chair: Patricia B. Hoyer, Ph.D. (University of Arizona, Tucson, Arizona, USA).
- Aileen Keating, Ph.D. (Iowa State University, Ames, Iowa, USA). Ovarian Metabolism of Xenobiotics (Abstract 121).
- Ronit Machtinger, M.D. (Brigham and Women's Hospital, Boston, Massachussets, USA). Bisphenol A (BPA) Exposure and Human Oocyte Meiotic Maturation (Abstract 122).
- Samantha F. Butts, M.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA). Smoking and Genetic Variation in Metabolism of Environmental Chemicals: A Model for Environmental Reproductive Toxicology (Abstract 123).
- Cornelia Post Channing New Investigator Competition. (Abstracts 124—127).
- The Cutting Edge—Follicle Reserve. Chair: Stephanie A. Pangas, Ph.D. (Baylor College of Medicine, Houston, Texas, USA).
- Blanche Capel, Ph.D. (Duke University, Durham, North Carolina, USA). Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates (Abstract 128).
- Stephen Franks, M.D., Ph.D. (Imperial College London, London, England, United Kingdom). Aberrant Follicle Development in Polycystic Ovary Syndrome: Implications for Fertility and Reproductive Lifespan (Abstract 129).
- ASRM Distinguished Research Exchange Lecture. Chair: Andrew R. LaBarbara, Ph.D. (American Society for Reproductive Medicine, Birmingham, Alabama, USA).
- Joe Leigh Simpson, M.D. (March of Dimes Foundation, White Plains, New York, USA). Genetic Causes of Premature Ovarian Failure (POF) (Abstract 130).
Module II C: Dynamics of Testicular Function. Room 105.
- Meiosis. Chair: Paula E. Cohen, Ph.D. (Cornell University, Ithaca, New York, USA).
- Mary Ann Handel, Ph.D. (The Jackson Laboratory, Bar Harbor, Maine, USA). Mutations Affecting Male Meiosis (Abstract 131).
- James M.A. Turner, M.D., Ph.D. (MRC National Institute for Medical Research, London, England, United Kingdom). Meiotic Silencing and Mammalian Infertility (Abstract 132).
- Platform Speaker: Tsutomu Endo, Ph.D. (Massachusetts Institute of Technology, Cambridge, Massachusetts, USA). Retinoic Acid Controls the Timing of Spermatogonial Differentiation and Meiotic Initiation in Adult Male Mice (Abstract 133).
- Platform Speaker: Tony J. DeFalco, Ph.D. (Duke University Medical Center, Durham, North Carolina, USA). Macrophage-mediated Regulation of the Spermatogonial Stem Cell Niche (Abstract 134).
- RNA Biology and Spermatogenesis I: Young Investigator Seminar. Chair: E. Mitch Eddy, Ph.D. (National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA).
- P. Jeremy Wang, M.D., Ph.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA). Biogenesis and Function of Pachytene piRNAs in Mice (Abstracts 135).
- Platform Speaker: Bart T. Phillips (University of Pittsburgh, Pittsburgh, Pennsylvania, USA). GDNF Signaling Regulates YBX1/MRNA Interactions in Mouse Spermatogonia (Abstract 136).
- Platform Speaker: Vesna Ann Chappell (East Carolina University, Greenville, North Carolina, USA). Translational Control During Fetal Male Germ Cell Development (Abstract 137).
- RNA Biology and Spermatogenesis II: Cutting Edge. Chair: Martin M. Matzuk, M.D., Ph.D.(Baylor College of Medicine, Houston, Texas, USA).
- Wei Yan, Ph.D. (University of Nevada School of Medicine, Reno, Nevada, USA). Occupy the Cell: We, Noncoding RNAs, Are the 99 Percent! (Abstract 138).
- Leendert Looijenga, Ph.D. (Erasmus Medical Center, Rotterdam, Netherlands). Clinical Impact of the Environmental Origin of Germ Cell Cancer (Abstract 139).
- Platform Speaker: Tracy M. Clement, Ph.D. (National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA). Testis Expressed Actin-like 7b (actl7b) Is Required for Mouse Spermatid Morphogenesis and Male Fertility (Abstract 140).
- Platform Speaker: Elsa Kichine, Ph.D. (McGill University, Montreal, Quebec, Canada). Analysis of the Sperm Head Protein Profiles in Normozoospermic Men: Consistency Across Time in the Levels of Expression of Heat-shock Proteins and Peroxiredoxins (Abstract 141).
Module III C: Reproductive Tract Biology and Pregnancy Outcomes. Room 108.
- Joint SSR-SGI Minisymposium on Endometriosis. Chair: Diego H. Castrillon, M.D., Ph.D. (University of Texas Southwestern Medical Center, Dallas, Texas, USA).
- Ov D. Slayden, Ph.D. (Oregon National Primate Research Center, Beaverton, Oregon, USA). Nonhuman Primate Models for Translational Research in Endometriosis (Abstract 142).
- Kathy L. Timms, Ph.D. (University of Missouri, Columbia, Missouri, USA). Rodent Models for Translational Research in Endometriosis (Abstract 143).
- Ayman Al-Hendy, M.D. (Meharry Medical College, Nashville, Tennessee, USA). Uterine Fibroids and Endometrial Dysfunctions (Abstract 144).
- Transgenerational Effects of Toxicants. Chair: Kevin G. Osteen, Ph.D. (Vanderbilt University School of Medicine, Nashville, Tennessee, USA).
- Kaylon L. Bruner-Tran, Ph.D. (Vanderbilt University Medical Center, Nashville, Tennessee, USA). Early Life Toxicant Exposure and Transgenerational Reproductive Consequences (Abstract 145).
- Platform Speaker: Wenan Qiang, M.D., Ph.D. (Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA). Down-regulation of mir-29b Is Essential for the Pathogenesis of Uterine Fibroids (Abstract 146).
- Platform Speaker: Monica M. Laronda, Ph.D. (Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA). SMAD-mediated TGFβ Family Signaling Regulates Epithelial Cell Fate in the Developing Vagina Through Expression of ΔNP63 (Abstract 147).
- Endometrial Cancer. Chair: Joanna E. Burdette, Ph.D. (University of Illinois at Chicago, Chicago, Illinois, USA).
- Jae-Wook Jeong, Ph.D. (Michigan State University, Grand Rapids, Michigan, USA). Understanding the Progression of Endometrial Cancer Using Animal Models (Abstract 148).
- Jose M. Teixeira, Ph.D. (Dana-Farber/Harvard Cancer Center, Boston, Massachusetts, USA). Contribution of the Endometrial Microenvironment to Carcinogenesis (Abstract 149).
- Platform Speaker: Hen Prizant (University of Rochester, Rochester, New York, USA). Uterine-specific Knockout of TSC2: A Mouse Model for Leiomyoma and LAM (Abstract 150).
- Platform Speaker: Mandy L. King (Southern Illinois University, Carbondale, Illinois, USA) Loss of Cdh1 and Tp53 Induces Neoplastic Transformation in Mouse Uterus (Abstract 151).
Module IV C: Reproductive Neuroendocrinology. Room 111.
- Hypothalamic Control of Reproduction. Chair: Prema Narayan, Ph.D. (Southern Illinois University School of Medicine, Carbondale, Illinois, USA).
- Tony M. Plant, Ph.D. (University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA). The Neurobiology of GnRH Pulsatility: A Mode of Hypothalamic Activity Essential for Follicugenesis, Ovulation, and Spermatogenesis (Abstract 152).
- Vincent Prevot, Ph.D. (INSERM, Lille, France). Semaphorin 3A/Neuropilin-1 Signaling Mediates GnRH System Development and Plasticity (Abstract 153).
- Platform Speaker: Jacob S. Moeller (University of Michigan, Ann Arbor, Michigan, USA). Developmental Programming: Increased Pituitary Sensitivity of Prenatal Testosterone-treated Sheep to GnRH Is a Function of Their Hyperinsulinemic Status (Abstract 154).
- Platform Speaker: Bruna R.C. Alves (Texas A&M University, College Station, Texas, USA). Accelerated Body Weight Gain During the Juvenile Period Alters the Neuropeptide Y-Kisspeptin Circuitry in the Hypothalamus of Prepubertal Heifers (Abstract 155).
- Young Investigator Seminar—The Foxy Pituitary: Emerging Roles for Forkhead Transcription Factors in Gonadotrope Development and Function. Chair: Lori Raetzman, Ph.D. (University of Illinois, Urbana, Illinois, USA).
- Varykina G. Thackray, Ph.D. (University of California, San Diego, California, USA). FoxO Regulation of Gonadotropin Hormone Synthesis in Pituitary Gonadotropes (Abstract 156).
- Buffy S. Ellsworth, Ph.D. (Southern Illinois University, Carbondale, Illinois, USA). The Forkhead Transcription Factor, Foxp3, is Required for Normal Pituitary Function (Abstract 157).
- Knocking Out Genes in Neuroendocrine Tissues. Chair: Tracy L. Davis, Ph.D. (University of Idaho, Moscow, Idaho, USA).
- Andrew Wolfe, Ph.D. (Johns Hopkins Hospital, Baltimore, Maryland, USA). Models for the Study of Metabolic and Gonadal Regulation of the Pituitary Gonadotroph (Abstract 158).
- Sally Camper, Ph.D. (University of Michigan, Ann Arbor, Michigan, USA). Genetics of Pituitary Insufficiency and Stem Cell Regulation: A Paradigm Shift (Abstract 159).
- Platform Speaker: Prema Narayan, Ph.D. (Southern Illinois University School of Medicine, Carbondale, Illinois, USA). Precocious Puberty, Elevated Steroidogenesis, and Leydig Cell Hyperplasia in Male Mice with a Gain of Function Mutation in the Luteinizing Hormone Receptor Gene (Abstract 160).
- Platform Speaker: Lan Hai (Southern Illinois University, Carbondale, Illinois, USA). Infertility, Ovarian Cysts, and Luteomas in Female Mice with an Activating Mutation in the Luteinizing Hormone Receptor Gene (Abstract 161).
5:30–6:00 pm
Trainee Awards Presentations. Forum Building, Room 108.
- Recognition of Burroughs Wellcome Fund Fellows and Junior Faculty (supported by the Burroughs Wellcome Fund). Presented by Carol C. Linder, Ph.D. (New Mexico Highlands University, Las Vegas, New Mexico), Chair, SSR Minority Affairs Committee.
- Recognition of Recipients of FASEB MARC Travel Awards (supported by the FASEB MARC Program, Bethesda, Maryland). Presented by Ms. Cordelia Adams (Federation of American Societies for Experimental Biology, Bethesda, Maryland), Program Coordinator, FASEB Office of MARC (Minority Access to Research Careers).
- Recognition of Lalor Foundation Merit Fellows (supported by the Lalor Foundation.)
- Recognition of Animal Research in Reproduction Fellowships (supported by a grant from Pfizer Animal Health).
- Presentation of Trainee Research Awards—Poster and Platform Competitions (supported by EMD Serono Research Institute).
- Presentation of the Cornelia Post Channing New Investigator Award.
6:00–7:00 pm
Business Meeting of the SSR Membership with Installation of Newly Elected SSR Officers and Directors. Forum Building, Room 108
Closing Ceremony. Forum Building, Room 108.
7:30 pm–12:30 am
Banquet (a.k.a. “Barbecue”) & Dance. Nittany Lion Inn.
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Thursday, 16 August 2012
Board of Directors Meeting.
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