SSR 2016 Scientific Program

**Dates, times, titles, speakers, and order of speakers in sessions are subject to change. Please visit the SSR 2016 News & Updates Blog for summarized updates.**

Keynote Address

  • Speaker: Eric Vilain, M.D., Ph.D. (University of California, Los Angeles, Los Angeles, California, USA). "Disorders/Difference of Sex Development: A World of Uncertainties."

State-of-the-Art Lectures

  • Speaker: Scott Fahrenkrug, Ph.D. (Recombinetics, Saint Paul, Minnesota, USA). Title to be announced.
  • Speaker: Eric Betzig, Ph.D. (Howard Hughes Medical Institute, Ashburn, Virginia, USA). "Imaging Life at High Spatiotemporal Resolution."

President's Symposium: Systems Biology of Reproduction

  • Speaker: Trey Ideker, Ph.D. (University of California, San Diego, La Jolla, California, USA). "Integrating Mutations and Variants Using Protein Networks.​"
  • Speaker: Elaine Ostrander, Ph.D. (National Human Genome Research Institute, Bethesda, Maryland, USA). "Personalized Medicine: Canine Genetics Leads the Way."
  • Speaker: Yoel Sadovsky, M.D. (Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA). "Molecular Signals at the Maternal-Placental-Fetal Communication Interface."
  • Speaker: Catherine Dulac, Ph.D. (Harvard University, Cambridge, Massachusetts, USA; and Howard Hughes Medical Institute, Chevy Chase, Maryland, USA). "Molecular Architecture of Social Behavior Circuits in the Mouse Brain."

Exchange Lectures

  • ASRM Distinguished Research Scientist: Frank Z. Stanczyk, Ph.D. (University of Southern California, Los Angeles, California, USA). "ParmacoKinetics and Receptor-Mediated Actions of Estrogens and Progestogens Used for Hormone Therapy in Postmenopausal Women."
  • SRF New Investigator: Amanda M. de Mestre, Ph.D. (Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom). "Molecular Mechanisms Regulating Early Placental Development in the Horse."
  • SSR New Investigator: Sarah Kimmins, Ph.D. (McGill University, Montréal, Québec, Canada). "Determining the Role of the Sperm Epigenome in Offspring Development and Health." Lecture supported by the Virendra B. Mahesh New Investigator Fund. 

Diversity Symposium

Supported by the Burroughs Wellcome Fund

  • Marino De Leon, Ph.D. (Loma Linda University, School of Medicine, Loma Linda, California, USA). "A Multifaceted Approach to Address Health Disparities."

Heritage Luncheon: Tribute to Anne McLaren, Ph.D.

  • Speaker: Blanche Capel, Ph.D. (Duke University, Durham, North Carolina, USA). "Anne McLaren: A Deep Love of Reproductive Biology and a Commitment ot Social Responsibility." 

FOCUS SESSIONS

Focus Session 1. Pathways to Normal and Disrupted Folliculogenesis

  • Chair: Lane K. Christenson, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA).
  • Invited Talk: Francesca E. Duncan, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA). "Age-Associated Alterations in Nucleolar Structure and Function during the Active Growth Phase of the Mammalian Oocyte."
  • Invited Talk: Aaron J. W. Hsueh, Ph.D. (Stanford University, Stanford, California, USA). "Ovarian Follicles: From In Vivo Architecture to In Vitro Activation."
  • Invited Talk: B.M. (Bart) Gadella, Ph.D. (Utrecht University, Utrecht, the Netherlands). "In Vitro and In Vivo Insights on the Impact of Circulatory Fatty Acids on the Last Maturation Phase of the Oocyte in Dairy Cows."
  • Additional talks will be selected from submitted abstracts.

Focus Session 2. Somatic Cells in Adult Testicular Function

  • Chair: Mark Hedger, Ph.D. (Hudson Institute of Medical Research, Clayton, Victoria, Australia).
  • Invited Talk: Jannette M. Dufour, Ph.D. (Texas Tech University, Lubbock, Texas, USA). "Sertoli Cells—Master Immune Regulators."
  • Invited Talk: Andreas Meinhardt, Ph.D. (Universität Giessen, Giessen, Hesse, Germany). "Cautious Defenders: What in the Testis Renders Testicular Macrophages So Special?" (tentative)
  • Invited Talk: Vimal Selvaraj, Ph.D. (Cornell University, Ithaca, New York, USA). "Mitochondrial Translocator Protein (TSPO): Redefining Its Function in Steroidogenic Cells."
  • Additional talks will be selected from submitted abstracts.

Focus Session 3. Conceptus-Uterine Interactions: Critical Players in Pregnancy Success

  • Chair: Thomas Spencer, Ph.D. (University of Missouri, Columbia, Missouri, USA).
  • Invited Talk: Adrian Erlebacher, M.D., Ph.D. (University of California San Francisco, San Francisco, California, USA). "Epigenetics of Decidual Inflammation."
  • Invited Talk: Fuller W. Bazer, Ph.D. (Texas A&M University, College Station, Texas, USA). "Interferon Tau: Role in Establishing and Maintenance of Pregnancy."
  • Invited Talk: Carlos Simón, M.D., Ph.D. (University of Valencia, Valencia, Spain). "The Dialog between the Maternal Endometrium and the Embryo: Potential Impact on the Onset of Adult Diseases."
  • Additional talks will be selected from submitted abstracts.

Focus Session 4. Gametogenesis In Vivo and In Vitro

  • Chair: Blanche Capel, Ph.D. (Duke University, Durham, North Carolina, USA).
  • Invited Talk: Takehiko Ogawa, M.D., Ph.D. (Yokohoma City University, Yokohama, Kanagawa, Japan). "In Vitro Spermatogenesis with Refined Organ Culture Methods."
  • Invited Talk: Mitinori Saitou, M.D., Ph.D. (Kyoto University, Kyoto, Kyoto, Japan). "Towards Understanding and Reconstitution In Vitro of Human Germ Cell Development."
  • Invited Talk: Erin F. Wolff, M.D. (NIH–NICHD, Bethesda, Maryland, USA). "Orthotopic Transplantation of Ovarian-Derived Stem Cells Results in Mature Oocytes That Can Fertilize and Undergo Embryo Development in Non-human Primates."
  • Additional talks will be selected from submitted abstracts.

Focus Session 5. Developmental Origins and Diabetes

  • Chair: Laura Clamon Schulz, Ph.D. (University of Missouri, Columbia, Missouri, USA).
  • Invited Talk: Rebecca A. Simmons, M.D. (University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA). "Programming: Is It Over Before Birth?"
  • Invited Talk: Theresa L. Powell, Ph.D. (University of Colorado Denver, Aurora, Colorado, USA). "Adiponectin: Maternal Adipose Tissue Programming of the Placenta and Fetus."
  • Invited Talk: Stephen Ford, Ph.D. (University of Wyoming, Laramie, Wyoming, USA). "Multigenerational Impact of Maternal Overnutrition/Obesity in a Sheep Model in Altering Offspring Phenotype."
  • Additional talks will be selected from submitted abstracts.

Focus Session 6. Optimizing Fertilization: Knowing the Players and Their Functions

  • Chair: Rafael A. Fissore, D.V.M., Ph.D. (University of Massachusetts, Amherst, Massachusetts, USA).
  • Invited Talk: Melina Schuh, Ph.D. (Medical Research Council, Cambridge, United Kingdom). Title to be announced.
  • Invited Talk: Jurrien Dean, M.D. (NIH–NIDDK, Bethesda, Maryland, USA). "Monospermic Fertilization Regulated by the Mouse Zona Pellucida."
  • Invited Talk: Christophe Arnoult, Ph.D., V.M.D. (Centre national de la recherche scientifique, University Grenoble Alpes, Grenoble, France). "Exomic Sequencing of Infertile Males Reveals Key Proteins of Sperm-Oocyte Physiology: Focus on Human Phospholipase C Zeta (PLCZeta)."
  • Invited Talk: Luca Jovine, Ph.D. (Karolinska Instituet, Huddinge, Sweden). "How Sperm and Egg Bind: From First Contact to Fusion."
  • Additional talks will be selected from submitted abstracts.

Focus Session 7. William Hansel Ovarian Symposium on Peri-ovulatory Ovarian Function—Preparing for Conception

  • Chair: Rebecca Robker, Ph.D. (Adelaide University, Adelaide, South Australia, Australia).
  • Invited Talk: Darryl Russell, Ph.D. (University of Adelaide, Adelaide, South Australia, Australia). "Mechanisms Coordinating Oocyte Developmental Potential and Ovulation."
  • Invited Talk: Misung Jo, Ph.D. (University of Kentucky, Lexington, Kentucky, USA). "The Ovulatory Process in the Human Ovary."
  • Invited Talk: Joy Pate, Ph.D. (Pennsylvania State University, University Park, Pennsylvania, USA). "Micromanaging the CL: Regulation of Transitional States in the Corpus Luteum by MicroRNA."
  • Additional talks will be selected from submitted abstracts.

Focus Session 8. Producing Functional Sperm

  • Chair: Prabhakara P. Reddi, Ph.D. (University of Illinois, Urbana, Illinois, USA).
  • Invited Talk: Patricia S. Cuasnicú, Ph.D. (IBYME-CONICET, Buenos Aires, Argentina). "From the Epididymis to the Egg." 
  • Invited Talk: George L. Gerton, Ph.D. (University of Pennsylvania, Philadelphia, Pennsylvania, USA). "Compartmentalization of metabolic enzymes in sperm and its impact on sperm functions." 
  • Invited Talk: Jean-Ju Chung, Ph.D. (Yale University, New Haven, Connecticut, USA). "CatSper Ca2+ Signaling Components in Sperm Motility and Fertility."
  • Additional talks will be selected from submitted abstracts.

Focus Session 9. Normal Uterine Development, Physiology, and Dysfunction

  • Chair: Vargheese M. Chennathukuzhi, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA).
  • Invited Talk: Milan K. Bagchi, Ph.D. (University of Illinois at Urbana-Champaign, Champaign, Illinois, USA). "Implantation: The Unveiling Continues."
  • Invited Talk: Aleksander Rajkovic, M.D., Ph.D. (Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA). "Med12 and Reproductive Pathology."
  • Invited Talk: Warren B. Nothnick, Ph.D. (University of Kansas Medical Center, Kansas City, Kansas, USA). "The Evolving Role of miR-451 in Endometriosis Pathophysiology."
  • Additional talks will be selected from submitted abstracts.

Focus Session 10. Testis Germline Stem Cell Niche

  • Chair: Brian P. Hermann, Ph.D. (University of Texas at San Antonio, San Antonio, Texas, USA).
  • Invited Talk: Yukiko Yamashita, Ph.D. (University of Michigan, Ann Arbor, Michigan, USA). "The Role of Satellite DNA in Drosophila Spermatogenesis."
  • Invited Talk: Tony J. DeFalco, Ph.D. (Cincinnati Children's, Cincinnati, Ohio, USA). "Macrophages and the Spermatogonial Niche."
  • Invited Talk: Nam D. Tran, M.D., Ph.D. (University of California, San Francisco, San Francisco, California, USA). "Suppression of the Abberantly Activated TNFa-NFkb Pathway in the Testicular Niche of Patients with Nonobstructive Azoospermia (NOA) Restores Spermatogonial Stem Cell Self-Renewal and Expansion."
  • Additional talks will be selected from submitted abstracts.

Focus Session 11. Environmental Effects on Development and Reproduction

  • Chair: Patricia Hunt, Ph.D. (Washington State University, Pullman, Washington, USA).
  • Invited Talk: Folami Y. Ideraabdulla, Ph.D. (University of North Carolina, Chapel Hill, North Carolina, USA). "Defining Epigenetic Consequences of Maternal Exposures."
  • Invited Talk: Zelieann R. Craig, Ph.D. (University of Arizona, Tucson, Arizona, USA). "Mechanisms of Phthalate-Induced Ovarian Follicle Toxicity."
  • Invited Talk: Laura N. Vandenberg, Ph.D. (University of Massachusetts Amherst, Amherst, Massachusetts, USA). "BPA Replacement Chemicals Force a Re-thinking of Critical Periods."
  • Additional talks will be selected from submitted abstracts.

Focus Session 12. Chromatin Regulation and Pre-implantation Programming of Cell Lineage

  • Chair: Keith Latham, Ph.D. (Michigan State University, East Lansing, Michigan, USA).
  • Invited Talk: Naojiro Minami, Ph.D. (Kyoto University, Kyoto, Kyoto, Japan). "CHD1 Is a Zygotic Determinant for Cell-Lineage Specification via the Hmgpi Pathway in Mouse Preimplantation Embryos."
  • Invited Talk: Brian D. Hendrich, Ph.D. (University of Cambridge, Cambridge, United Kingdom). "Transcriptional Control of Cell Fate."
  • Invited Talk: Jesse Mager, Ph.D. (University of Massachusetts Amherst, Amherst, Massachusetts, USA). "Functional Screening of the Preimplantation Transcriptome."
  • Additional talks will be selected from submitted abstracts.

Focus Session 13. Somatic Stem Cells and Gynecologic Cancers

  • Chair: Barbara Vanderhyden, Ph.D. (Ottawa Hospital Research Institute, Ottawa, Ontario, Canada).
  • Invited Talk: Nick Barker, Ph.D. (Institute of Medical Biology, Singapore). "Lgr5+ Stem Cells Contribute to OSE Formation and Repair in Vivo."
  • Invited Talk: Sanaz Memarzadeh, M.D., Ph.D. (University of California, Los Angeles, Los Angeles, California, USA). "Disarming Mechanisms of Platinum Resistance in High Grade Serous Cancer Stem Cells."
  • Invited Talk: Bo Rueda, Ph.D. (Massachusetts General Hospital, Boston, Massachusetts, USA). "Utilizing a Tumor-Specific Carbohydrate Antigen to Target Ovarian Cancer Stem Cells."
  • Additional talks will be selected from submitted abstracts.

Focus Session 14. Post-testicular Regulation of Male Fertility

  • Chair: Sylvie Breton, Ph.D. (Massachusetts General Hospital, Boston, Massachusetts, USA).
  • Invited Talk: Barry T. Hinton, Ph.D. (University of Virginia, Charlottesville, Virginia, USA). "Examination of the Dynamic Nature of Wolffian/Epididymal Duct Morphogenesis."
  • Invited Talk: Sylvie Breton, Ph.D. (Massachusetts General Hospital, Boston, Massachusetts, USA). "Basal Cell Motility in the Epididymis Revealed by In Vivo Imaging: Regulation by the Tyrosine Kinase Pathway."
  • Invited Talk: Martin J. Cohn, Ph.D. (University of Florida, Gainesville, Florida, USA). "Sexual Differentiation of Vertebrate External Genitalia."
  • Additional talks will be selected from submitted abstracts.

Focus Session 15. Uterine-Placental Function During Gestation

  • Chair: Ronald Magness, Ph.D. (University of Wisconsin, Madison, Wisconsin, USA).
  • Invited Talk: Kent Thornburg, Ph.D. (Oregon Health & Science University, Portland, Oregon, USA). "Placental Plasticity and Influence on Lifelong Cardiovascular Disease."
  • Invited Talk: Ronald Magness, Ph.D. (University of Wisconsin, Madison, Wisconsin, USA). "Mechanisms Controlling Endothelial Adaptations Modulating of Uterine and Placental Blood Flows During Gestation."
  • Invited Talk: Berthold Huppertz, Ph.D. (Medical University of Graz, Graz, Austria). "Etiology of Preeclampsia: What Are the Roles of Oxygen and (Anti-) Angiogenic Factors?"
  • SRF New Investigator: Amanda M. de Mestre, Ph.D. (Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom). "Molecular Mechanisms Regulating Early Placental Development in the Horse."
  • Additional talks will be selected from submitted abstracts.

Focus Session 16. Cell Divisions in Germ Cells and Early Embryos

Supported, in full, by Asia Pacific Biomedical Research Foundation (APBRF).

  • Chair: Greg FitzHarris, Ph.D. (Université de Montréal, Montréal, Quebec, Canada).
  • Invited Talk: Anne Villeneuve, Ph.D. (Stanford University, Stanford, California, USA). "Mechanisms Ensuring the Formation of Euploid Gametes."
  • Invited Talk: Marie-Emilie Terret, Ph.D. (INSERM, Collège de France, Paris, France). "F-actin Mechanics Operate the Asymmetric to Symmetric Division Switch at the Oocyte-to-Embryo Transition."
  • Invited Talk: Kazuo Yamagata, Ph.D. (Kinki University, Higashiosaka, Osaka, Japan). "Quantification of Embryo Quality by Live-cell Imaging."
  • Additional talks will be selected from submitted abstracts.

Focus Session 17. Neuroendocrinology at the Intersection of Fertility and Metabolism

Supported by the Viresh Neuroendocrine Program Fund

  • Chair: Lori T. Raetzman, Ph.D. (University of Illinois, Urbana, Illinois, USA).
  • Invited Talk: Alexander (Sasha) Kauffman, Ph.D. (University of California, San Diego, La Jolla, California, USA). "Emerging Roles of Kisspeptin Signaling Beyond the Reproductive Axis: Insight from Mouse Models."
  • Invited Talk: Ursula B. Kaiser, M.D. (Brigham and Women's Hospital, Boston, Massachusetts, USA). "The Elusive Link between Leptin Signaling and Reproduction."
  • Invited Talk: Djurdjica Coss, Ph.D. (University of California, Riverside, Riverside, California, USA). "Crossroads in the Hypothalamus: Effects of Obesity on Reproduction."
  • Additional talks will be selected from submitted abstracts.

Focus Session 18. Bringing In Vitro Maturation of Oocytes from Bench to Bedside

  • Chair: Johan Smitz, M.D., Ph.D. (UZ Brussel, Brussels, Belgium).
  • Invited Talk: Claude Robert, Ph.D. (Université Laval, Québec City, Québec, Canada). "Unexpected Contributions from the Cumulus Cells to Support Oocyte Quality."
  • Invited Talk: Robert B. Gilchrist, D.Sc.Agr. (University of New South Wales, Sydney, New South Wales, Australia). "Translating Scientific Advances in Oocyte Biology to the IVM Clinic."
  • Invited Talk: Johan Smitz, M.D., Ph.D. (UZ Brussel, Brussels, Belgium). "Bringing In Vitro Maturation of Oocytes from Bench to Bedside."
  • ASRM Distinguished Research Scientist: Frank Z. Stanczyk, Ph.D. (University of Southern California, Los Angeles, California, USA). "ParmacoKinetics and Receptor-Mediated Actions of Estrogens and Progestogens Used for Hormone Therapy in Postmenopausal Women."
  • Additional talks will be selected from submitted abstracts.
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